Effects of Donepezil on Behavioral Manifestations of Thalamic Infarction: A Single-Case Observation
نویسندگان
چکیده
OBJECTIVE To examine the effect of donepezil for the treatment of cognitive and behavioral disorders associated with thalamic lesions in a 45-year-old male who suffered an infarct in the left thalamus. BACKGROUND Recent studies suggest that donepezil may improve executive functions impairments due to subcortical ischemic lesions. METHOD The effects of donepezil were analyzed in a single-case of thalamic infarction with cognitive and behavioral alterations in an open label study. RESULTS Significant behavioral modifications related to improved performances in executive functions were observed with the treatment. CONCLUSION The results suggest that donepezil may have significant effect on executive functions that can alter behavioral outcomes after thalamic infarctions.
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